What's wrong with this picture? It's a mural on the side of Pearson's Rexall Drug Store in Houston, Mississippi. It depicts the front of the building, as the "driver" is approaching the corner, and the drug store sits across the street from the courthouse (not visible) and the post office. Assuming the presence of the horse and buggy represents pre-automobile days, that would place the time of the town at least prior to 1927 or so when gasoline powered automobiles became more common. The Houston post office depicted in the mural was built in 1939-40.
Unfortunately, the Mississippi Department of Archives and History database, on which I heavily depend, does not identify many Houston buildings, and even fewer by address. The Coca-Cola mural appears on the side of a building on the Courthouse square, which I would guess dates from the late 1800s. Just be advised that if you plan on doing your holiday shopping in Houston, don't park on the square in front of the stores. You'll be there for a while.